There are numerous different systems to deliver drugs or supplements into the body.
There are important advantages and benefits to each.
Sublingual/Buccal (One of the most effective.)
Sublingual and baccal drugs or supplements refer to the administration of drugs or supplements absorbed directly into the bloodstream through the rich layers of blood vessels found in the mouth
*****These forms of administration bypass the gastrointestional tract.*****
Sublingual drugs or supplements are administrated by placing the substance under the tongue. It is rapidly absorbed into the blood stream. Example: Nitroglycerine.
Baccual drugs or supplements are placed between the cheek and the gum where they are quickly absorbed into the bloodstream Example: B-Natal.
Liquid herbal tinctures like Essiac Herbals and Wild Parsley are examples of products taken both sublingual and buccal.
Transdermal delivery is generally used to describe drugs or supplements being absorbed into the layers of the skin. They avoid the effects of the gastrointestional tract and first-pass metabolism. There are two main forms of transdermal delivery devices.
These are systemetically-active drugs or supplements. When applied topically, they are absorbed first into the blood circulation and then transported to target tissues, which could be far away from the site of application. Placed on the skin, the therapeutic patch delivers the active ingredient or drug for days and can maintain a steady and even state of delivery. Examples: testosterone patches (male hormone, estrodial patches (female hormone), nicotine patches (smoking cessation program). Topical Creams or Serums:
For many decades, the skin has been commonly used as the site for the administration of drugs or supplements. The drug or supplement deffuses to the target tissues in the proximity of the application to produce the therapeutic effect before it is distributed to the blood circulation for elimination. These transdermal creams/serums act on the skin and are not systemic. Examples: hydrocortisone cream, benzoyl peroxide cream, neomycin and cosmetics. Other examples: Endocreme 900 Balancing Serum or Cream, Progenix, Promenix, Ibuderm, Dhea, and Glucosamine.
For years European consumsers have enjoyed the many benefits of taking effervencent vitamin supplement drinks. Aside from the obvious advantage of convenience, effervescent drinks are easy on the stomach, easily digested, and more easily absorbed by the body. In addition to making nutraceutical formulations convenient and bioavailable, effervescent drinks enhance the bioavilability of certain hard to absorb nutrients. They also reduce the gastric upset that is often associated with taking supplements.
The greatest benefit of effervescents is one of the least known. The most critical and potentially limiting factor in taking any supplement formulation is administerating the proper dose. This is known as efficacious dosage, and it's not always easy. The efficacious dose for some supplements is so great, consumers have to take 4 to 5 tablets or capsules of each ingredient in order to achieve the disired benefit. Ultimately, patient complience becomes an issue. For the thousands of consumers who have difficulty swallowing pills, effervescent drinks are a lifesaver. Effervencent technology reduces the difficulty of patient complience, and ensures the proper dose is administrater with each serving.
The Benefits of Effervescents:
*** Individually packaged single serving doses
*** Easy to swallow
*** Increased absorption
*** Enhanced bioavailability
*** Easy on the stomach
*** Efficacious dosing
*** Guaranteed fresh until activated with water or fluid
These productss are administrated outside the GI tract. They are generally restricted to injectables.
There are two main forms of Parenteral delivery systems: Intravenous and Intramuscular.
Intravenous drugs are placed directly into the blood. Intravenous drugs usually require hospitalization because of their need for continuous and frequent drug level monitoring. Example: intravenous fluids.
Intramuscular/Subcutaneous drugs are injected into the muscules where a depot is formed at the site of the injection, which acts as a reservior for the drug. The drug will then be released continuously from the reservior.
Oral administration of drugs or supplements is the most common delivery method, which includes pills, tablets, capsules, and soft gels. They are the most common because of the convenience and low cost.