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Promenix
USING A "STATE OF THE ART" DELIVERY SYSTEM & IT'S TIME RELEASED!!
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Item Number: AL 02
Price:
$20.00
Quantity:
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Promenix utilizes a liposome delivery system. Lipsomes are hollow spears made
form phospholipids that are 300 times smaller than skin cells. This
transdermal "delivery system" is a realitively new development and gaining
quickly in acceptance. Well known examples are etrogen and nicotine patches. A
growing amount of reaserch has proven that these fat soluable substnaces are
more bioabvailable to the body than equivalent doses when taken orally. In
other words, if taken by mouth in pill or capsule form, these substances
supply only a small percentage of the needed biological activity when compared
with the smae dose amount used in liposomes.
Oral use is dependent on proper gastrointestional absorption, after
which metabolization takes place in the liver. This is known as first pass
through the liver. Therefore, liposomes are considered to be more economical,
efficient and beneficial. The added advantage is that the liver has less work
to do.
Stastics show that 50% of men over age 40 experience problems with their
prostate. By the time they are 70, over 60% of
American men will have an enlarged prostate gland called Benign Prostate
Hypertrophy or BPH. At age 80, the number goes up to 85%. Symptoms of BPH
include dribbling, frequent or difficult urination, decrease in urine stream
and chronic discomfort in the pelvis area. These symptoms can disrupt sleep in
many cases. Moreover, the prostate gland is also the most common site for
cancer to develop with one in 11 American men over age 50 will develope
prostate cancer.
Hormonal imbalances are at the root of the wide spread problems
associated with the prostate gland. Other contributing factors are a high fat
diet and enviromental estrogens from plastics, pesticides, as well as
synthetic hormones fed to cattle. Deficiencies in vital nutrients such as zinc
can also play a role in the development of prostate disorders.
To explain the hormonal influence on prostate disorders it is important
to understand the effect of two hormones on the prostate gland;
Dihydrotesterone (DHT) is a hormone synthesized from testosterone and
estrogen. Both are thought to contribute to prostate enlargement.
An enzyme called 5-alpha reductase is responsible for converting
testosterone to DHT. In normal amounts, DHT has positive effects on male
health. However, if excess cells in the prostate proliferate at an abnormal
rate and enlargement occures. This being the case, 5-alpha reductase
inhibitors reduce the rate of synthesis of DHT from testosterone.
Progesterone, the herb Saw Palmetto, and zinc are known 5-alpha reductase
inhibitors.
Though testosterone is the primary male hormone men do produce some
estrogen. In fact, it is converted from testosterone. Unfortunately, with age
testosterone production decreases and estrogen production increases. Once
again an enzyme is involved in this hormone imbalance. Aromatase, especially
prevalent in fat cells, converts testosterone to estrogen. Since most men lose
muscle and gain fat as they age, aromatase activity increases, converting the
now lower levels of testosterone to estrogen. Evidence now indicates that
prostate hypertrophy (enlargement) and prostate cancer are correlated with the
condition of excess estrogen. Not only does the activity of aromatase increase
with weight gain, men are exposed to enviromental estrogens contributing to
the estrogen burden. One of the major roles of progesterone is to oppose or
balance the effects of estrogen in the body. Estradiol, an aggressive estrogen
promotes the onco (cancer) gene, Bcl-2, while progesterone promotes the
protective gene known as p53.
A growing body of scientific research supports the use of progesterone,
Saw Palmetto, and zinc for the health of the prostate.
These substances have now been shown to be absorbed well through the
skin and in combination could offer a viable solution to prostate problems for
men.
Research Highlights:
Progesterone
*Progesterone is a 5-alpha reductase inhibitor--it helps
prevent the conversion of testosterone into DHT which is thought to contribute
to prostate enlargement.
*Research now indicates that progesterone inhibits the growth of
prostate cancer cells and that estradiol and dihydrotestosterone (DHT)
accelerate prostate cancer cell growth. Progersterone opposes estrogen and its
metabolites and it stops the conversion of testosterone to DHT by interfering
with the enzyme 5- alpha reductase.
*Progesterone may induce mutated prostate cells to enter into the
apoptosis (programmed death) cycle, and cell proliferation should be minized.
Clinicians have related case histories of men with benign prostate disease and
cancer who have found relief with progesterone.
*In 1988 a study conducted at Nanjing Medical College in China found
progesterone reduced the prostate weight of test animals.
*Six different studies at the University of Milan in Italy, the
University of Turku in Finland, Montreal General Hospital in Quebec, St.
George's Hostital in London, the University of Mainz in Germany and the
Roswell Park Memeorial Institute in New York all independently had results
that suggest that progesterone is a powerful 5-alpha reductase inhibitor that
stops the conversion of testosterone into DHT in test animals.
*At the University of Maryland in Baltomore and the Institute of
Clinical Medicine in Rome, human prostate cells were shown to have
progesterone receptor sites.
*The Center for Drug Research in India did four different studies
suggesting that progesterone shrank enlarged rat prostates, progesterone
antagonized the stimulating effects of estrogen, and that progesterone is
supportive of proper prostate function.
*At the University of Laval in Quebec progesterone inhibited estrogen
from binding to the prostate and progesterone receptors were clearly
demonstrated.
*At the Institute for Biological Medical Experiments in Buenos Aires it
was shown progesterone shrank prostate weight in test animals as well as
reduced 5-alpha reductase activity.
*At Central Hosapital University in Paris progesterone was shown to
inhibit the formation of DHT as well as binding it to the prostate. DHT
content in the prostate is the single most causative factor in prostate
disease.
*At the Biochemical Medical Laboratory in France the doctors
demonstrated in human BPH tissue there are more progesterone receptors which
show how responsive the prostate is to this hormone.
*At the Institute of Clinical Chemistry in Bochum, Germany progesterone
in human BPH tissue reduced the activity of 5-alpha reductase strongly.
Saw Palmetto
*Saw Palmetto has been extensively prublished in studies for
its ability to support the treatment of enlarged prostate glands in men.
*Saw Palmetto has shown to effectively block the formation of DHT and is
also believed to provent the binding of dihydrotesterone (DHT) to androgen
receptors.
*Saw Palmetto inhibits 5-alpha-reductase, the enzyme that converts
testosterone to diydrotestosterone and also block DHT from binding in the
prostate.
*Studies on Saw Palmetto found no significant side effects.
*Saw Palmetto may also help to reduce the effects of excess estrogen.
Zinc
*The zinc content of the protate gland prostatic, secretions
and sperm is higher than in any other body tissues. A deficiency of zinc is
associated with numerous sexual problems, including sperm abnormalities and
prostate disease. Zinc is necessary for the production of testosterone.
*Zinc has anti-aromatase action, aromatase converts testosterone to
estradiol.
*Zinc is also a 5-alpha-reductse inhibitor, which blocks the conversion
of testosterone to DHT, therefore, zinc may be beneifical to conditions
related to excess DHT, according to a recent study conducted at the Center of
Reproductive Science and Technoloigy, University of Missouri, Columbia and
published in the journal Andrologia.
*All body tissues contain zinc; in skin it is five to six times more
concentrated in the epidermis than the dermis. Research conducted at Duke
University and published in the International Journal of Dermatology
found that topical zinc may provide an important and helpful antioxidant
defense for skin.
*Other research published in Geriatric Dermatology
demonstrates that topical zinc is well absorbed by the skin in aging men.
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All Prices in US Dollars
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